논문검색
Author Ju-Han Lee, M.D., Suk-Min Lee, M.D. and Jong-Sang Choi, M.D.
Place of duty Department of Pathology, College of Medicine, Korea University, Seoul, Korea
Title Prognostic Significance of KAI-1 and Survivin Expressions in Ovarian Epithelial Carcinomas
Publicationinfo Cancer Research and Treatment 2003 Aug; 035(04): 323-329.
Key_word Ovary neoplasm, Survivin, KAI-1
Full-Text
Abstract Purpose: The purpose of this study was to evaluate the expressions of KAI-1 and survivin, and to investigate their correlation with the clinical stage and survival rate of patients with ovarian carcinomas. Material and Method: The expressions of survivin and KAI-1 were immunohistochemically determined in 54 serous and mucinousovarian adenocarcinoma and borderline malignancy tumors. 10 of the 54 cases were also analyzed for the expressions of survivin and KAI-1 using western blot. Results: The down-regulation of the expression of KAI-1 was observed by immunohistochemical staining (IHC) in 53.7% of the ovarian cancers, and a negative reaction in 50% by the western blot analysis. From the IHC, the survivin expression was positive and strongly positive in 51.9 and 18% of the ovarian cancers, respectively. From the western blot analysis, 10% of the ovarian cancer showed positive reactions. The down-regulation of the KAI-1 expression was significantly correlated with the clinical stage (p=0.001) and disease free survival rate (p<0.001), but not with the histological type. The expression of survivin was not correlated with the clinical stage or histological type. However, the patients with a negative survivin expression had a significantly longer disease survival rate than those with a strong positive expression. Conclusion: The down- and up-regulation of the KAI-1 and survivin, respectively, might be independent prognostic factors in human ovarian carcinomas. (Cancer Research and Treatment 2003;35:323-329